Alkermes
demonstrated dose dependent increases in exposure and wakefulness pharmacodynamics strong relationship demonstrated in rat model suggests potential for low human dose did not adversely elevate heart rate and blood pressure in a rat hemodynamic model at pharmacologically relevant plasma exposures alkermes data on file time time | Alkermes
Company
Deck Type
Sector
Industry
Deck date
March 2021
Slide
139 of 144
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group average changes in beta power for low dose and high dose groups per time point average differences in each time point is compared to zero and time points with significant changes test were marked with asterisk preliminary data subject to change phase the effect was also time dependent showing a rapid onset of effect a delayed pharmacodynamic curve | ATAI
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