ATAI Investor Presentation Deck
June 2020, 49 slides
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company overview june company overview healing mental health disorders so that everyone everywhere can live a more life | ATAI
| ATAI
mental health disorders have become one of global health burdens depression rates of us adults saw a increase since the onset of the covid pandemic as a response to the technical risks associated with drug development focuses on compound classes with prior evidence in humans and utilizes a decentralized drug development process active programs drug and discovery programs and enabling technologies focusing on potentially disease modifying therapies validation of operating model of compass pathways and validating license deal between perception we have a strong cash position of as of march with runway into life sciences healing so that everyone everywhere can live more life | ATAI
founder chairman brand founder founder weaver the team has collectively led through regulatory approval applications a founder led aiming to develop differentiated treatments for patients suffering from mental health disorders | ATAI
our objective achieve clinically meaningful and sustained change in patients diagnosed with mental health disorders key pillars rapid acting intervention focus ongoing support focus precision mental health focus and generation compounds that result in rapid acting improvement of mental health disorders additional care that is provided to patients before during and after initial treatment interventions the identification of patient sub types using biological and digital achieving through a combined approach | ATAI
we will deliver on our strategy through a robust pipeline with drug development programs across several mental health indications with large unmet need | ATAI
the platform enables improved probabilities of success across the pipeline via decentralized drug development entrepreneurial teams and matrix framework | ATAI
milestone highlights in anticipated catalysts across we will build on recent success by delivering several meaningful our key programs | ATAI
depression | ATAI
urgent need for innovation inadequate response rate slow onset of treatment effect long term side effects approvals since depression | ATAI
summary phase trial showed a rapid sustained reduction in depressive symptoms | ATAI
summary we aim to develop as a rapid acting with potential for at home use | ATAI
in preclinical models higher potency longer lasting effect and lower potential for abuse | ATAI
phase data dosing showed minimal to no | ATAI
subjects parallel arms of subjects data expected by year end placebo and intravenous primary depression rating scale at hours clinician administered dissociative states scale cadss key safety tolerability running across multiple sites in and the phase comparative study to bridge from to a subcutaneous formulation currently in progress phase study will be completed this year randomized establish human proof of concept | ATAI
depression positioning and landscape programs are designed to be differentiated from one another and from competitors | ATAI
cognitive associated with schizophrenia | ATAI
huge need for development lost life expectancy low treatment rate cognitive impairment is very common approvals for schizophrenia | ATAI
demonstrated pro cognitive treatment for developed product in licensed with extensive clinical clinical data package human phase data show replicated clinically significant learning and memory effects consistent with broad clinical pro cognitive data well tolerated subjects dosed centrally acting oral drug initial indication cognitive impairment associated with schizophrenia is characterized by episodic learning and memory deficits no approved treatment a risked excellent tolerability | ATAI
summary has previously shown pro cognitive effects in human clinical studies | ATAI
low doses enhanced learning and memory verbal learning delayed recall dose phase exploratory patients dose additionally a study in of also showed statistically significant positive cognitive signals | ATAI
phase a study showed wide spread beneficial changes | ATAI
schizophrenia landscape unique pharmacology acute cognitive benefit and excellent tolerability differentiate it from the current standard of care available to schizophrenia patients | ATAI
anxiety | ATAI
massive unaddressed need gad sufferers in the us low treatment rate anxiety depression are complimentary limited treatment options | ATAI
has the potential for like rapid onset efficacy with improved safety and tolerability | ATAI
there is an unmet need in gad for therapies with rapid onset high efficacy and minimal side effects can fill generalized anxiety disorder favorable safety profile | ATAI
substance use disorder | ATAI
an ongoing pandemic number of sufferers in us high relapse rates drug overdose deaths increase treatment options for | ATAI
a single dose of showed potential for sustained reductions in cravings in dependent patients | ATAI
summary could potentially become a paradigm shifting therapy for use disorder current standard of care for is medication therapy requiring substitutes that carry significant side effects current strategies for withdrawal support have high rates of relapse has the potential to the first best in class treatment minimizing risk | ATAI
drug discovery enabling | ATAI
drug discovery enabling technologies our are designed to drive efficient and improved treatment outcomes introspect | ATAI
stratification focused platform companies dedicated towards advancements in formulation our provide an additional avenue of growth innovation to the | ATAI
digital therapeutics data analytics platform deploy digital therapeutics in combination with compounds to improve efficacy and safety and to drive sustained behavioral change create a centralized proprietary data analytics platform to characterize the disease of our target indications and develop patient targeting algorithms integrated platform based brain computer interface that provides a digital guide experience introspect digital application that delivers continuous personalized clinical psychotherapy modal data collection focusing on platform digital via platform clinical research station efforts are focused using we are creating better patients | ATAI
engines established to operate in a highly complementary manner our discovery are driving further pipeline innovation by developing next generation compounds utilizing state of the art approaches | ATAI
financial overview | ATAI
issuer ticker life sciences market capitalization outstanding shares cash cash equivalents million as of march is well financed to fund planned operations into we have runway | ATAI
depression portfolio positioning landscape prior data the story of where they are headed appendix | ATAI
depression portfolio positioning landscape | ATAI
depression positioning and landscape is targeting via multiple complementary approaches | ATAI
prior data | ATAI
is active in a broad range of clinical cognition models enhances cognition in mouse rat and dog species reverses scopolamine induced memory deficit in both tox species consistent inverted shaped relationship across species pro cognitive effects translate to humans was pharmacologically defined using electrophysiology also | ATAI
phase reverses cholinergic memory challenge better than significantly reverses memory deficits at dose and delays recovery at extremely high dose continuity of attention delayed word recall the effects on delayed word recall were more marked than seen with the target clinical dose of the most widely prescribed anti drug prior study showed positive cognitive signals | ATAI
the story of their future | ATAI
early research suggested in mental health novel results and regulatory support underscore therapeutic value a resurgence therapies is emerging as promising disease modifying drug candidates progress with momentum | ATAI
i felt like just like a whole new reborn person i had not felt that happy in a long long time i felt way better about myself when i had a craving something in my head quickly thought about the good part the taste the feeling the high right but if i think of the drug now i quickly think about the downside it changed the perception i have regarding the drug it sort of relieved a lot of stress a lot of negative thoughts within my body opened my eyes to see where my stress and conflict is coming from it is hard to explain but it just brought a lot of grief up that i had inside me it brought it out and i got rid of a lot of grief male male female patient reports study more than half patients ranked | ATAI
while mental health is the initial focus adjacent indications may allow for significant expansion anti inflammatory properties make potentially interesting for a variety of therapeutic indications selected interest therapeutics | ATAI
brand life sciences watching my best friend and business partner suffer being let down by existing treatments and finally finding comfort in therapies was all the inspiration i needed to commit my to this cause | ATAI
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