BioNTech Investor Day Presentation Deck
June 2022, 156 slides
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innovation series | BioNTech
this slide presentation includes forward looking statements | BioNTech
safety information | BioNTech
safety information | BioNTech
agenda innovation series | BioNTech
welcome | BioNTech
the human immune system plays a central role in of human diseases | BioNTech
the tools we have developed for cancer will enable us to treat many diseases | BioNTech
taking from vision to reality | BioNTech
strong momentum built on two decades of innovation i clinical | BioNTech
today | BioNTech
advancing toward our long term vision | BioNTech
the approach to innovation | BioNTech
focused on five innovation pillars | BioNTech
| BioNTech
understanding and exploiting immunological mechanisms | BioNTech
focused on five innovation pillars | BioNTech
mutation based cancer heterogeneity the root cause of cancer therapy failure | BioNTech
mutations from cancer tissues are and of mutations are immunogenic when exploited as vaccine targets | BioNTech
exploiting the for personalized vaccination | BioNTech
acquisition of the patient tissue and blood samples sat a | BioNTech
identification of the patient cancer mutations cancer | BioNTech
prediction of mutations | BioNTech
individualized vaccine manufacturing | BioNTech
how do different types of induce cell responses and kill tumors | BioNTech
absolute frequency of genes selected for vaccination across trials the long tail of individual targets trials | BioNTech
focused on five innovation pillars | BioNTech
platform strategy technology agnostic innovation engine | BioNTech
technology broad built out of deep immunological a | BioNTech
technology each format is optimized for specific applications | BioNTech
technology sarna could induce higher and extended in and in expression compared to backbone optimized | BioNTech
technology amplifying could potentially be a vaccine strategy to induce potent immunity | BioNTech
technology we are exploring and sarna in multiple infectious disease programs | BioNTech
delivery formulations a diversified and rationally designed delivery platform for medicine hin spleen | BioNTech
delivery formulations a diversified and rationally designed delivery platform for medicine | BioNTech
focused on five innovation pillars | BioNTech
applications prediction covid variants monitoring and prediction | BioNTech
prediction drive individualized cancer medicine | BioNTech
prediction how do we identify predict and characterize | BioNTech
prediction individualized targets not all are created equal of | BioNTech
prediction genomic and drive our individualized target | BioNTech
prediction new based immune response model may improve accuracy of prediction based | BioNTech
covid variants monitoring and prediction reduction in time to detect new variants of concern by months be | BioNTech
covid variants monitoring and prediction predicted scores for immune escape and fitness prior correlate with in data | BioNTech
covid variants monitoring and prediction report june | BioNTech
focused on five innovation pillars | BioNTech
manufacturing and | BioNTech
diversified manufacturing across four distinct capabilities | BioNTech
expanding global manufacturing footprint | BioNTech
scaling up manufacturing | BioNTech
scaling up batch numbers | BioNTech
manufacturing innovation cycle time reduction with process | BioNTech
we are investing in global cell therapy infrastructures | BioNTech
a platform for localized and sustainable production | BioNTech
what is next in | BioNTech
focused on five innovation pillars to enable a new era of synthetic medicine | BioNTech
focused on five innovation pillars to enable a new era of synthetic medicine | BioNTech
platform innovation engine | BioNTech
new frontiers in new frontiers in infectious diseases infectious diseases | BioNTech
building on covid vaccine leadership to address global challenges | BioNTech
medical burden from infectious diseases is a growing global challenge top | BioNTech
covid vaccine validates our technology and paves the way for future products billion | BioNTech
and global collaboration programs in infectious diseases influenza | BioNTech
well prepared for the next phase of covid pandemic billion doses delivered to of countries and regions key drivers | BioNTech
granted for pediatric use low dose vaccination safely high protection | BioNTech
variant adapted vaccines next generation vaccine approaches aim to provide durable variant protection variant adapted and next generation vaccine approaches | BioNTech
variant adapted vaccines omicron consistent with simple superiority criterion for omicron modified vaccines participants a titer pug bivalent lug | BioNTech
variant adapted vaccines omicron consistent with super superiority criterion for monovalent omicron modified vaccine participants bivalent lug titer | BioNTech
variant adapted vaccines omicron rate exceeds criterion for omicron containing vaccines participants bivalent | BioNTech
variant adapted vaccines in participants without evidence of infection up to month after study vaccination immunogenicity subset a | BioNTech
variant adapted vaccines profile of variant vaccines overall similar to prototype vaccine | BioNTech
variant adapted vaccines omicron containing modified variant vaccine summary | BioNTech
variant adapted vaccines epidemiology changes quickly vaccine updates need to adapt with the pace of the virus | BioNTech
variant adapted vaccines omicron has more than all other variants combined | BioNTech
variant adapted vaccines and are now increasing in prevalence | BioNTech
variant adapted vaccines omicron and sequences are distinct from and | BioNTech
variant adapted vaccines omicron containing modified variant vaccines as dose elicit improved omicron neutralization response | BioNTech
omicron monovalent and bivalent boosters in mice substantially increase omicron neutralization responses to all omicron variants including and reference strain a | BioNTech
variant adapted vaccines omicron variant adapted vaccines increase omicron sub lineages ref titer ratio in mice | BioNTech
variant adapted vaccines a science driven preparedness strategy | BioNTech
pandemic preparedness an integrated faceted model for future pandemic preparedness a | BioNTech
malaria tuberculosis and remain endemic million cases million cases deaths million deaths deaths with | BioNTech
building an manufacturing network to address infectious diseases in and beyond | BioNTech
urgent need for next generation precision antibacterials million million effective the resistance by and severe bacterial infections | BioNTech
synthetic lysins a potentially ideal class of precision antibacterials fig | BioNTech
diverse and modular domain architecture allows flexibility in engineering | BioNTech
are highly potent and allow laser focused modulation | BioNTech
expanding opportunities in infectious diseases first in human vaccine trial starts expected in | BioNTech
a | BioNTech
time for a break | BioNTech
oncology pipeline | BioNTech
understanding and exploiting immunological mechanisms | BioNTech
oncology pipeline significant progress and expansion in | BioNTech
unique combination potential across platforms | BioNTech
cancer vaccines | BioNTech
vaccines for enabling potent targeting of cancers | BioNTech
driving continuous innovation with data | BioNTech
phase as and in combination with | BioNTech
vaccines are well suited for the early line setting | BioNTech
phase open label randomized trial in advanced melanoma gee | BioNTech
high medical need in the adjuvant treatment of stage high risk stage cancer ill | BioNTech
phase randomized trial watchful waiting in adjuvant cancer gee | BioNTech
phase trial of adjuvant in pancreatic adenocarcinoma is | BioNTech
substantial and durable cell expansion observed in immune responders after treatment gee | BioNTech
functional cells confirmed by in immune responders gee | BioNTech
immune response correlates with delayed recurrence in adjuvant gee | BioNTech
leveraging shared tumor associated antigens for cancer treatment | BioNTech
treatment options needed to address failure in advanced melanoma me | BioNTech
durable responses in a phase trial in advanced experienced melanoma experienced | BioNTech
long duration of clinical responses observed for patients receiving and combination with gee | BioNTech
tumor shrinkage observed in patients receiving or combination with a inhibitor | BioNTech
strong immunogenicity and promising clinical activity in phase merit | BioNTech
phase randomized trial in patients with anti melanoma is success measures | BioNTech
cancer vaccines near term milestones | BioNTech
protein therapeutics | BioNTech
combining blockade and conditional cell stimulation | BioNTech
first in human phase trial in heavily advanced solid tumors | BioNTech
initial results in dose show a manageable safety profile with most aes being grade or protein therapeutics | BioNTech
anti tumor activity phase dose part | BioNTech
clinical activity in patients with experienced relapsed refractory experienced | BioNTech
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