Erasca IPO Presentation Deck
July 2021, 46 slides
  1. Erasca
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corporate presentation | Erasca
| Erasca
offering summary | Erasca
our name is our mission to erase cancer | Erasca
leadership team has experience and drive to make a difference | Erasca
sab includes world leading experts in the ras pathway | Erasca
lives at stake annually with ras pathway alterations | Erasca
of unmet needs are blue ocean with limited no treatment options | Erasca
our singular focus is on the ras pathway | Erasca
deep modality agnostic ras pathway focused pipeline | Erasca
our pipeline targets every node on the ras pathway | Erasca
companies with common cause of targeting ras to defeat cancer eras corm | Erasca
as the most distal node within ras pathway is a critical target | Erasca
eras is a promising inhibitor in a field marked by attrition | Erasca
we believe eras is the most potent inhibitor in development | Erasca
eras uniquely long target residence time may enable dosing flexibility | Erasca
competitive inhibitors are more robust in shutting down | Erasca
other plus inhibitor combinations mask i a a i a foe a | Erasca
eras showed strong in combination activity in | Erasca
eras showed strong in combination activity in | Erasca
eras showed strong in activity in kras mutant models | Erasca
eras phase responses observed in patients with ras and alterations in diverse tumor types with single agent schedule | Erasca
swimmer plot demonstrated encouraging duration of treatment | Erasca
examples of single agent clinical activity of eras responses in melanoma and salivary gland adenocarcinoma pease | Erasca
eras schedule was better tolerated than | Erasca
eras recommended dose was well tolerated with minimal grade and no grade | Erasca
phase data showed is preferable to dosing simulations suggest bid dosing may improve profiles and even more | Erasca
is a critical on off switch that activates bound kras signaling | Erasca
eras demonstrated biochemically potent and selective inhibition | Erasca
eras showed superior potency to across cell lines a esophageal | Erasca
eras also showed superior potency to across cell lines | Erasca
eras demonstrated favorable physicochemical and properties which support its development as a combination therapy | Erasca
combination of eras eras showed strong in activity in kras mutant models | Erasca
era | Erasca
| Erasca
eras first in human study | Erasca
| Erasca
at turned kras from to | Erasca
we have discovered promising penetrant kras candidates i | Erasca
| Erasca
| Erasca
beyond targeting kras and other ras mutations | Erasca
our franchise programs are highly differentiated | Erasca
tissue specific and tissue agnostic trials target multiple indications | Erasca
value inflection points with steady anticipated | Erasca
compelling investment thesis | Erasca
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