Nuvalent
preclinical exhibits potent activity across diverse fusion partners and resistance mutations | Nuvalent
Company
Deck Type
Sector
Industry
Deck date
October 2023
Slide
13 of 52
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Investor Presentation
April 2024
preclinical characterization demonstrates desired target product profile inhibited diverse alk fusions and resistance mutations in activity in activity potent activity against alk driven cell lines including alk single and compound mutants tumor regression at well tolerated doses in alk models including alk single and compound mutants a a a a a a poe arn i i a vehicle cell lines harboring alk fusion day cell viability assay no resistance mutations a a a a a a a a a models harboring alk fusion no resistance mutations hip alk a i alk mem alk alk alk a alk bid bid or in some cases dosing was not performed on weekends bid twice daily half maximal inhibitory concentration orally once daily variant sources lin lee data also reflect additional repeat testing models a a | Nuvalent
Investor Presentation
February 2024
preclinical characterization demonstrates desired target product profile inhibited diverse alk fusions and resistance mutations in activity in activity potent activity against alk driven cell lines including alk single and compound mutants tumor regression at well tolerated doses in alk models including alk single and compound mutants a so apt of me gee a a a eer ere a a a a vehicle cell lines harboring alk fusion a no resistance mutations a day cell viability assay a a a a a bid twice daily half maximal inhibitory concentration orally once daily variant models harboring alk fusion no resistance mutations hip alk alk alk alk alk a alk bid bid or in some cases dosing was not performed on weekends sources lin data also reflect additional repeat testing and models lee a a a | Nuvalent
Investor Presentation
January 2024
preclinical characterization demonstrates desired target product profile inhibited diverse alk fusions and resistance mutations in activity in activity potent activity against alk driven cell lines including alk single and compound mutants tumor regression at well tolerated doses in alk models including alk single and compound mutants i is a eye of a a a a i i a a a a vehicle call lines alk fusion day cell viability assay no resistance mutations a a a a a a a a a i models harboring alk fusion no resistance mutations hip alk alk alk alk me alk a alk bid bid or in some cases dosing was not performed on weekends bid twice daily half maximal inhibitory concentration orally once daily variant sources lin lee a a data also reflect additional repeat testing and models | Nuvalent
Investor Presentation
January 2024
preclinical characterization demonstrates desired target product profile inhibited diverse alk fusions and resistance mutations in activity in activity potent activity against alk driven cell lines including alk single and compound mutants tumor regression at well tolerated doses in alk models including alk single and compound mutants i is a eye of a a a a i i a a a a vehicle call lines alk fusion day cell viability assay no resistance mutations a a a a a a a a a i models harboring alk fusion no resistance mutations hip alk alk alk alk me alk a alk bid bid or in some cases dosing was not performed on weekends bid twice daily half maximal inhibitory concentration orally once daily variant sources lin lee a a data also reflect additional repeat testing and models | Nuvalent
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