Nuvalent
preclinical characterization demonstrates desired target product profile broad activity on her alterations including her exon ins activating point mutations and amplified wild type her i greater selectivity for her mutations over than pan inhibitors selectivity index more active for her a phospho in a phospho her or viability wild type phospho her viability her her her her her her her her her her her phospho her her knock in her her her her her her her phospho a data similar to observations for brain exposure rats han rats single dose hour no head to head clinical studies have been conducted for currently approved or investigational therapies versus above data from studies her her exon insertion half maximal inhibitory concentration orally source sun | Nuvalent
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Industry
Deck date
April 2024
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preclinical characterization demonstrates desired target product profile in activity wild type mutant brain penetrance avoiding inhibition sub activity in day cell viability assays data similar to observations for selectivity for and over we a we a a a i a a a i a expressing or mutant fusion wild type han rats single dose hour more active for me more active for a selectivity index head to head clinical studies comparing with currently approved or investigational therapies have not been conducted above data from studies bid twice daily half maximal inhibitory concentration patient derived cell line orally stimulated phosphorylation sources a cancer a a | Nuvalent
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preclinical characterization demonstrates desired target product profile in activity wild type mutant brain penetrance avoiding inhibition sub activity in day cell viability assays data similar to observations for selectivity for and over is expressing or mutant fusion wild type han rats me single dose hour more active for nest a more active for selectivity index sax ors head to head clinical studies comparing with currently approved or investigational therapies have not been conducted above data from studies bid twice daily half maximal inhibitory concentration patient derived cell line orally stimulated phosphorylation sources a cancer a a | Nuvalent
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